Pharmacological Management of Common Gynecological Pathologies: Comprehensive Review of Therapeutic Strategies and Clinical Applications
Keywords:
gynecological pathologies, pharmacological treatment, endometriosis, PCOS, uterine fibroids, immunotherapy, hormonal therapy, GnRH agonistsAbstract
Gynecological pathologies represent significant global health challenges affecting women of reproductive age. This comprehensive review examines the pharmacological management of endometriosis, polycystic ovary syndrome (PCOS), uterine fibroids, menorrhagia, dysmenorrhea, and gynecological malignancies. Current therapeutic approaches include hormonal therapies (progestins, GnRH agonists/antagonists, combined oral contraceptives), selective progesterone receptor modulators (SPRMs), insulin sensitizers, and emerging immunotherapies. Recent advances demonstrate superior efficacy of novel agents such as elagolix, linzagolix, ulipristal acetate, and checkpoint inhibitors (pembrolizumab, dostarlimab) in specific pathologies. This review synthesizes current evidence regarding drug mechanisms, comparative efficacy, adverse effects, and emerging treatment paradigms based on 60 recent publications and clinical trials.
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