Consequences of Damage to Renal Parenchyma and Microcirculatory Bed in Arterial Hypertension Associated with Diabetes Mellitus
Keywords:
diabetes mellitus, arterial hypertension, diabetic nephropathy, renal parenchyma, microcirculation, albuminuria, eGFR, renal resistive indexAbstract
Objective. To evaluate the clinical and laboratory consequences of damage to the renal parenchyma and microcirculatory bed in patients with arterial hypertension associated with diabetes mellitus, and to determine the relationship between albuminuria, eGFR, renal Doppler parameters, and microcirculation markers.A conditional clinical observational study included 90 patients. The patients were divided into three groups: Group 1 — patients with type 2 diabetes mellitus and arterial hypertension, n=45; Group 2 — patients with type 2 diabetes mellitus without arterial hypertension, n=25; Group 3 — patients with arterial hypertension without diabetes mellitus, n=20.In all patients, blood pressure, HbA1c, creatinine, eGFR, urinary albumin-to-creatinine ratio, renal ultrasound, renal parenchymal thickness, renal Doppler resistive index, and peripheral microcirculation parameters were assessed. Statistical analysis included ANOVA, the Kruskal–Wallis test, the χ² test, Spearman correlation analysis, multivariate regression analysis, and ROC analysis.
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